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Some individuals report losing 8 to 12 pounds during this window, while others experience a slower, more gradual decline

FUNDING This work was supported by the National Natural Science Foundation of China (82300903), the Key R&D Plan Social Development Project of Jiangsu Province (SBE2023741128), the National Natural Science Foundationof Jiangsu Province (SBK20 23022865), the sixth phase 333 second level talent training project of Jiangsu Province (tackling bottleneck technology) (BRA2022008), the Projects from Social Development of Zhenjiang (SH2023029), the Youth Science and Technology Talent Recruitment Project of Zhenjiang city (ZJTJ2101), the Affiliated Hospital of Jiangsu University Beigu Talent Cultivation Plan Project (BGYCB202206), the Affiliated Hospital of Jiangsu University Doctoral Initiation Fund Project (jdfykc2021005)

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In addition, GLP-1RA can not only inhibit the PI3K/Akt signaling pathway after activating GLP-1R (13) but also downregulate the expression levels of Cyclin A2 and Cyclin D1,which are markers of cell proliferation related to downstream pathways (95)