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Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X et al (2004) p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene

Incretin-based therapies are also being investigated in other indications and across several organs, and as such, have completely changed the treatment landscape for a variety of metabolic diseases

We also demonstrate the utility of HRMS discovery-based approach (sometimes referred to as pharmacometabolomics in clinical applications ( 35, 36 )) to advance a step forward towards precision and personalized medicine and uncover new metabolites markers that can be used to provide better typing of patients related to the kinetic of elimination of a drug or to identify inter-individual susceptibility to develop drug-induced liver injury, as it is the case here with APAP