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Importance of Aggregate Analysis Aggregates may: Alter pharmacokinetic behavior Increase immunogenicity risk Reduce therapeutic potency Impact formulation stability Analytical Challenges Aggregate characterization often requires: Orthogonal analytical methods SEC coupled with MS Native mass spectrometry Stability-indicating analytical workflows Using multiple complementary techniques improves confidence in impurity detection and biosimilar comparability

Depression without periods of mania is sometimes referred to as unipolar depression because the mood remains at the bottom "pole" and does not climb to the higher, manic "pole" as in bipolar disorder

A case report on use of dulaglutide during the first weeks of pregnancy in woman affected by type 2 diabetes mellitus

In reality, bodies respond differently to food, movement, and sleep, and these differences matter