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A new clinical trial, co-led by endocrinologist and diabetes expert John Buse, MD, PhD, and interventional cardiologist Matthew Cavender, MD, MPH, at the UNC School of Medicine has shown that the oral form of semaglutide can significantly reduce cardiovascular events in people with type 2 diabetes and atherosclerotic cardiovascular disease, and/or chronic kidney disease

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Genetic variation in GLP1R (GLP-1 receptor), GIPR (glucose-dependent insulinotropic polypeptide receptor), FTO (fat mass and obesity-associated), and MC4R (melanocortin-4 receptor) genes significantly influences how individuals respond to semaglutide versus tirzepatide