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The reasons for these failures often include short in vivo half-life, chemical instability, limited cellular uptake, poor bioavailability, lack of targeted delivery to specific tissues or (sub)cellular compartments, a narrow therapeutic index, and toxicity

Chrononutrition refers to aligning food intake patterns (timing, frequency, and composition of meals) with the bodys circadian clock to optimize metabolic health and sleep-wake rhythms

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[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Glucagon-like peptide-1 receptor agonists as potential myelination-inducible and anti-demyelinating remedies