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Therefore, in contrast to most conventional antibiotics that perturb the homeostasis of normal microbiota, the antivirulence approach intends to target and inhibit the molecules and structures vital for bacteria to inflict disease [89]

However, it can have **negative** effects on redness, irritated skin, acne, and sensitive skin

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Mol Cell 14(3):395403 Latres E, Amini AR, Amini AA, Griffiths J, Martin FJ, Wei Y, Lin HC, Yancopoulos GD, Glass DJ (2005) Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway