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The reason is straightforward Retatrutide already causes significant metabolic changes on its own, and adding a second compound too early makes it hard to identify which peptide is responsible for any side effects that pop up
Additional costs apply, including consultation, ongoing care, and side effect management
Nature 534 , 213217 (2016)
Sci Rep (2022) 12:10484
Clinical trials of GLP-1 patches have consistently shown lower and more variable absorption compared to subcutaneous injections, meaning patients experience less predictable appetite suppression and metabolic effects
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