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They copy a natural hormone called glucagon-like peptide-1 (GLP-1), which your gut releases after eating

How It Works By activating both GIP and GLP-1 receptors, tirzepatide provides a dual-action approach to appetite control, blood sugar regulation, and metabolic enhancement

"Imaging the electromechanical activity of the heart in vivo." Proc Natl Acad Sci U S A 108 (2011a): 8565-8570

However, the peptide nature of tirzepatide creates substantial challenges for oral delivery, including degradation in the gastrointestinal tract and poor absorption across intestinal barriers

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