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Due to its targeted structure and functional design, AOD-9604 has become a compound of interest in metabolic and peptide-based research

doi: 10.1016/j.cmet.2024.04.004 71 TaoHLiWZhangWYangCZhangCLiangXet al

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Administration of MTX (5 mg/kg) to day 4 produced a significant decrease in hepatic glutathione (GSH) levels and a significant increase in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) liver enzymes, hepatic malondialdehyde (MDA), tumor suppressor protein (p53), Il-6 and IL-1 levels compared to the control group

In another in vivo study, a reduction in levels of testosterone and an increase in levels of LH and FSH were seen after NAC supplementation among adult male Wistar rats (Reference Moghadam, Shariati and Naeimi16)