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However, drug use and unhealthy diet lead to microbial dysbiosis, triggering metabolic disorders and adversely affecting kidney health ( Figure 2 ) [24, 36]

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They add that as immunotherapies are being more commonly utilized as first- and second-line treatments, immunotoxicity and autoimmunity are emerging as the Achilles heel of immunotherapy. In their Cancer Immunology Research paper, Bluestone and colleagues briefly discuss immunotherapeutic strategies that can potentially prevent irAEs, such as targeting intratumoral T cells directly, using bispecific antibodies to enhance localized targeting of tumor, and using engineered cell therapies to fine-tune immune cell responses

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Metformin and an insulin/IGF-1 receptor inhibitor are synergistic in blocking growth of triple-negative breast cancer