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Semaglutide works by slowing stomach emptying and signaling fullness to the brainwhich can trigger mild to moderate nausea in the first 48 weeks

The "Muscle Loss" Concern: Recent 2025-2026 data emphasizes the importance of high protein intake and resistance training on these meds to prevent losing too much lean muscle mass

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This steady phase is expected and does not mean the medication has stopped working

Metformin Blunts Muscle Hypertrophy in Response to Progressive Resistance Exercise Training in Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial: The MASTERS Trial