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This is probably related to the drugs incretin effect.20 The demonstrated potential of SEMA to reduce adipose accumulation at the lingual level may represent an additional mechanismbeyond weight lossfor improving the control of sleep apnoea.22 The SCALE programme also demonstrated the ability of LIRA 3 mg to improve cardiovascular risk factors (CVRFs), including blood pressure, lipid profile and inflammation markers.13 The effects on glycaemic control and CVRFs associated with SEMA 2.4 mg in the STEP programme are qualitatively similar, but quantitatively superior to those observed with LIRA 3 mg, possibly related to the different weight loss.16 The SELECT study, conducted with SEMA 2.4 mg, consistently showed a reduction of major adverse cardiac events (MACE) of triple composite endpoint (non-fatal myocardial infarction, non-fatal stroke, cardiovascular mortality) of 20% relative to placebo in a population with established cardiovascular disease and BMI greater than 27 kg/m2 without diabetes after 39.8 months of follow-up.23 Although a direct role of SEMA cannot be ruled out, the influence of adipose reduction and the improvement of adipocyte dysfunction probably contribute to the evolving profile of cardiovascular risk factors
10.1021/tx00034a019
10.1097/00000441-200002000-00002 [DOI] [PubMed] [Google Scholar] 169.Jialal I, Devaraj S, Venugopal SK
10.1016/j.cell.2017.07.032 10.1016/j.cell.2017.07.032 [DOI] [PMC free article] [PubMed] [Google Scholar] Creagan ET, Moertel CG, O'Fallon JR et al (1979) Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer
It usually resolves within 5-7 days at the new dose
