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The findings suggest that combining GHK-Cu and HA can enhance dermal-epidermal junction (DEJ) health by stimulating collagen IV synthesis

Furthermore, adding to the complexity of this process, allosteric activators have been described that bind to sites distinct from the orthosteric binding pocket of the receptor (Zhao et al., 2020), thereby necessitating a highly precise preselection of compounds to be used as lead candidates

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