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It is a broad growth, proliferation, and angiogenesis signaling system, and it is dysregulated or overexpressed in several cancers

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The frequency and severity of these events may differ

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Many authors discuss the inadequacy of guidelines when written based on general consensus and expert opinion, rather than on high-level clinical evidence, noting that case reports, retro/prospective studies, and observational studies, as is mostly what is currently available, are often insufficient to inform clinical practice (Australian Diabetes Society, National Association of Clinical Obesity Services, Gastroenterological Society of Australia, and Australian and New Zealand College of Anaesthetists n.d.)