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Side Effects: How They Compare Both drugs share a very similar side effect profile because both act on the GLP-1 receptor

Toussaint, D.M

MT-IIs activation of MC3R and MC4R in mesolimbic dopamine circuits , including the ventral tegmental area and nucleus accumbens and modulates dopamine release and dopamine receptor signalling in reward and motivation circuits

In vivo rodent models have explored tissue-specific IGF-1R engagement by comparing the biodistribution and signalling footprint of IGF-1 LR3 against the native 70-amino acid ligand