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FDA PCAC 2023 What this means practically for research dosage decisions: Doses above 1 mg/day are not supported by efficacy data and appear to produce diminishing returns

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Compounded medications do not undergo pre-market review or an FDA-approval process

This shows that while cytosolic Ca 2+ levels in Tgn-treated cells may be partially rebalanced, Ms4a15 OE cells are refractory to uptake