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Autophagy 14, 16461648

flat or raised Variable colors (pink, tan, brown) but usually uniform within a lesion Usually small circumscribed and symmetric Junctional melanocytic proliferation, if present Predominant nested pattern, rare solitary units of melanocytes Most melanocytic nests are at tips of rete ridges Dermal nevus component Evidence of maturation Often orderly nested growth pattern Often symmetric wedge or plaque-like growth pattern Lack of marked atypia and mitoses Possible associated features: Epidermal hyperplasia with hyperkeratosis (keratotic nevus) Papillomatous epidermal hyperplasia (papillomatous nevus) Balloon cell changes (balloon cell nevus) Inflammation and regression (e.g., halo nevus) Fatty metaplasia of the dermal stroma Many others (e.g., calcifications, oncocytic changes) Compound and dermal nevi typically show zonation with depth (so-called maturation) in the dermis

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Wegovy coverage for weight management is growing but inconsistent