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Interestingly, Pseudomonas nitroreducens GGT (PnGGT) exhibits higher hydrolytic activity than transpeptidase activity despite high sequence similarity with EcGGT ( Picrophilus torridus GGT (PtGGT), the replacement of an aromatic residue tyrosine at position 327 by asparagine (corresponding residue in EcGGT) introduced significant transpeptidase activity in PtGGT, while the native enzyme exhibited only hydrolytic activity ( Importance of Lid Loop in Catalysis The presence of a unique lid-loop region in the small subunit of GGT of different bacterial and mammalian homologues as shown in multiple sequence alignment (Supplementary Figure 1) has structural and functional significance

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Sleep architecture optimization DSIP appears to specifically promote delta wave sleep, also called slow-wave sleep or deep sleep

Increased glucuronidation of thyroid hormone in hexachlorobenzene-treated rats