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The pharmacokinetics and bioavailability of quercetin and its proportion in herbal medicine will also be discussed

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Studies have shown that reducing the content of FMO3 in insulin-resistant mice can inhibit FoxO1 (the central node of metabolic control), reduce the production of TMAO, and completely prevent the development of hyperglycemia, hyperlipidemia, and atherosclerosis (84)

Integration with metabolic therapies: since senescent adipose tissue, liver steatosis and visceral fat contribute to metabolic decline, FOXO4-DRI might improve metabolic resilience

For this reason, we are interested in investigating the role of IGF-1 in these signaling pathways in chondrocytes (in vitro) and the rabbit model during OA progression