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The most common cause of melanosis coli is the extended use of laxatives, and commonly anthraquinone containing laxatives such as Senna and other plant glycosides

However, both a low rate and the excessively high rate of methylation have the potential to cause cellular dysfunction, to interfere with the finely tuned, complex interactions of metabolic pathways related to or independent of NO production

Remarkably, NTS neurons are also the main source of locally produced GLP-1 in the brain

Introduction Glutathione is a naturally occurring tripeptide widely recognized for its powerful antioxidant properties and essential role in cellular protection

Targeting these molecules with neutralizing antibodies or small-molecule antagonists (e.g., glycyrrhizin) has demonstrated BBB-stabilizing effects in vivo , including reductions in brain edema and vascular permeability (Lochhead et al., 2020