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Cash, J

The H-site is highly hydrophobic and variations in its topology are important for the substrate selectivity of the enzyme

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A list of common conditions besides pernicious anemia associated with a B12 deficiency includes the following: Crohns disease Celiac disease Atrophic gastritis, otherwise known as a thinning of the stomach lining Bacteria or parasites in the intestines Immune system disorders, including Graves disease and lupus Inflammatory bowel disease (IBD) Medications Medications can also interfere with B12 absorption, such as some heartburn medicines and proton pump inhibitors prescribed to diabetics