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CC carriers), but no significant effect was observed for those living in northern regions of the globe (Costa-Lima et al., 2008

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Blood pressure: mild transient effects at high doses in animal models

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In the phase 3 REDEFINE 1 trial, the combination of cagrilintide and semaglutide yielded a mean 20% reduction in body weight over 68 weeks in adults with overweight or obesity, significantly outperforming placebo and either agent alone