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GLP-1 based therapies: clinical implications for gastric emptying

At the population level, complications from obesity rise as BMI increases [ For years, T2DM has been viewed as a chronic, progressive condition necessitating continual adjustment of pharmacotherapy, with estimates that 50% of patients will require insulin dependence within 910 years [ The discovery that glucagon-like peptide-1 (GLP-1) enhances insulin secretion in a glucose-dependent manner and suppresses glucagon release while minimizing the risk of hypoglycemia has led to the development of various structurally distinct GLP-1 receptor (GLP-1R) agonists (GLP-1RAs) with longer circulation times for the management of T2DM [Figure 1)

Peptides like GLP-1 (Ozempic) and ipamorelin represent larger peptide categories with metabolic and anabolic effects that can indirectly influence sexual health and fertility

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Tsang, S