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The primary study endpoint was the percentage of participants with a pain VAS reduction of 20 mm at 30 days of treatment
Suitable for intramuscular or intravenous administration
Also avoiding heavy fat meals may help
No Hematopoietic Effect: ARA-290 does not bind to the homodimeric EPO receptor (EPOR/EPOR) responsible for red blood cell production
Based on the sequence requirements in penetratin for transduction, such as hydrophobicity, amphipathicity, basicity, and the chain length (Khafagy et al., 2010a), a modified peptide designated as shuffle (R,K fix) 2 (RWFKIQMQIRRWKNKK) that exhibits safe and enhanced insulin delivery was developed (Khafagy et al., 2010a)
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