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What we know Several large, observational studies found no association between vitamin C intake and hypertension

Metformin treatment in heart failure with preserved ejection fraction: a systematic review and meta-regression analysis

doi: 10.3389/fonc.2026.1748136 Received 18 November 2025 Revised 23 March 2026 Accepted 24 March 2026 Published 30 April 2026 Volume 16 - 2026 Edited by Pierfranco Conte, University of Padua, Italy Reviewed by Valeria Conti, University of Salerno, Italy T Mohan Viswanathan, Karpagam Academy of Higher Education, India Updates Copyright 2026 Talath, El-Tanani, Wali, Rabbani, Bhongande, Ibraheem, Avagimyan, Hoffmann, Ilias, Ispas, Viviana, Paczkowska and Rizzo

The reduced state is ready to neutralize free radicals while the oxidized glutathione performs other functions