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Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation

On efficacy, orforglipron sits between oral semaglutide and injected tirzepatide

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Another PKA-independent mechanism of GLP-1 stimulation of insulin secretion includes PKC-dependent membrane depolarization via activation of transient receptor potential cation channel subfamily M member 4 (Trpm4) and Trpm5 [514]

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