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Yes, supplementing vitamin B12 is generally very safe and beneficial especially in cases with gastrointestinal disease coupled with weight loss

Mannose ameliorates experimental colitis by protecting intestinal barrier integrity

Specific situations that require prompt medical discussion include: experiencing persistent or severe gastrointestinal side effects (nausea, vomiting, diarrhea, or abdominal pain) that make you want to reduce dosing frequency

The reconstituted solution must be refrigerated immediately and used within the timeframe specified by your pharmacy

The body quickly builds a tolerance to it, meaning that after a few weeks or months, the same dose no longer produces the same appetite-suppressing effect