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The primary concern relates not to direct drug interactions between most injectable GLP-1 agonists and levothyroxine, but rather to the potential impact on thyroid monitoring and the theoretical risk associated with thyroid C-cell tumours observed in animal studies

Suppression of myopathic lamin mutations by muscle-specific activation of AMPK and modulation of downstream signaling

Age impairs this process causing lipofuscin accumulation in RPE

Cagrilintide is a synthetic, acylated 39-amino acid peptide modified with a C20 di-acid fatty acid side chain for enhanced albumin binding

But because there arent published human clinical trials on KPV, we simply dont yet know how this translates to humans, what dosing ranges are best, or whether it's safe over the long term