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Why the FDA Boxed Warning Exists The FDA boxed warning states GLP-1 receptor agonists should not be used in patients with MTC history or MEN2

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In general, males should aim for 125 ounces (3.7 liters) of fluids per day, and females should consume 95 ounces (2.7 liters) per day, according to the National Academy of Sports Medicine

Agarwal notes that these cases are relatively rare