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Developing a definition for oral antidiabetic drug (OAD) failure

Robust Anti-Obesity and Metabolic Effects of a Dual GLP-1/Glucagon Receptor Peptide Agonist in Rodents and non-Human Primates

Each of these 3 incretins have somewhat different effects, both at the gut level and via the brain, regarding reduced appetite, increased energy expenditure, nutrient storage and substrate utilization, insulin secretion, promotion of satiety, delay of gastric emptying, or reduced systemic inflammation

Fiber undergoes bacterial fermentation in the colon, producing short-chain fatty acids (SCFAs)particularly butyrate, propionate, and acetatewhich can stimulate L-cell GLP-1 secretion

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