Studies have shown that all 15 GLP-1 medications significantly reduce HbA1c and fasting blood glucose levels compared to placebo
Oral GLP-1 options Oral formulations represent an emerging alternative to injectable GLP-1 medications
Aborted LR3 clinical studies in oncology (late 1990s) highlighted the complexity of IGF-1R targeting: mitogenic potential on mammary and prostate tumor lines, requiring abandonment of development in favor of IGF-1R antagonists (monoclonal antibodies such as figitumumab, ganitumab, dalotuzumab) which also encountered phase III failures but enriched understanding of the IGF axis role in carcinogenesis
Legido A, Goldenthal MJ, Garvin B, Damle S, Corrigan K, Connell JE, Thao D, Valencia I, Melvin JJ, Khurana DS, Grant M, Newschaffer CJ (2018) Effect of a combination of carnitine, coenzyme Q10 and alpha-lipoic acid (MitoCocktail) on mitochondrial function and neurobehavioral performance in children with autism spectrum disorder (P3.313)
Bioengineered 12 , 41504158 (2021)
