Feedback suppression of meal-induced glucagon-like peptide-1 (GLP-1) secretion mediated through elevations in intact GLP-1 caused by dipeptidyl peptidase-4 inhibition: a randomized, prospective comparison of sitagliptin and vildagliptin treatment
In addition, 31.6% of Zepbound participants lost 25% of body weight compared to 16.1% of participants who used Wegovy
Minelli C, Granell R, Newson R, Rose-Zerilli MJ, Torrent M, Ring SM, et al
Eligible beneficiaries must meet the clinical criteria at the time of GLP-1 therapy initiation
Considering these findings observed across a large, real-world cohort, the researchers concluded that avoidance of semaglutide based solely on concerns regarding the risk of NAION may not be warranted, as its potential benefits for blood glucose control and cardiovascular health likely outweigh its potential risks.