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Aminoglycosides, tetracyclines, and certain other antibiotics may alter gut microbiota composition, potentially affecting the small amount of vitamin B12 that is produced by colonic bacteria, though this is generally not clinically significant for patients receiving injectable B12 supplementation

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Older Adults Older individuals sometimes experience more fatigue on semaglutide because their metabolic flexibility (ability to adapt to different fuel sources) may be reduced compared to younger people

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