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Prostaglandins generated by particularly the COX-2 enzyme, have a key role in ulcer healing process by increasing blood flow, stimulating mucosal bicarbonate secretion, preventing the disruption of mucosal barrier, accelerating cell proliferation and enhancing angiogenesis (Poonam et al

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Regarding the treatment of NAFLD or NASH, there are recent guidelines for NAFLD/NASH published by AASLD (2018) and AACE (2022) [36,37]

This is also supported by additional biochemical results