oral semaglutide nejm 25 mg and Orforglipron for Obesity: New Insights Drug Watch: The oral version

Ozempic works through multiple pathways to influence blood pressure levels in patients with type 2 diabetes

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He was surprised that although the [very low-calorie diet] resulted in greater reductions in weight, fat mass, and insulin resistance, it did not appear to enhance beta cell function. The authors suggest that this is because the participants had been living with type 2 diabetes for a long time

(This source provides background on the mechanisms of GLP-1 analogues)

Both suppress appetite, slow gastric emptying, and have produced meaningful weight loss in large clinical trials