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The temperature employed to evaporate solvent from the microdroplets is not critical, but should not be that high that it degrades the agent employed in the preparation of a given microparticle, nor should it be so high as to evaporate solvent at such a rapid rate to cause defects in the wall forming material

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Folate, particularly methylfolate, can worsen this by further increasing SERT and dopamine transporter (DERT) activity, potentially leading to increased anxiety, OCD-like symptoms, emotional instability, and cognitive rigidity