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Experimental studies and theoretical calculations of Ebselen and its analogs revealed that strong selenium oxygen/nitrogen interactions in selenenyl sulfide intermediates have adverse effects on the biological activity of selenium compounds, mainly due to thiol exchange reactions (Bhabak and Mugesh 2010)
Hesperidin protected against oxidative stress, neurotoxicity, Herpes simplex virus infection, apoptosis, atherogenesis, inflammatory bowel disease, arthritis, platelet and erythrocyte aggregation and infection [40-50]