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THE FIT PROGRAM INCLUDED ADULT PATIENTS WITH CHRONIC ITP WHO HAD RECEIVED 1 PRIOR THERAPY FIT program patients were representative of the general adult chronic ITP population, including exposure to prior therapies TAVALISSE dosing 3 Starting dose of TAVALISSE: One 100 mg tablet BID Based on platelet count and tolerability, the dose could be increased to one 150 mg tablet BID at or after week 4 Patients who had a platelet count 50 x 10 9 /L at the time of rollover to the FIT-3 open-label extension study maintained their existing dose of TAVALISSE References: 1

Clomiphene, a selective estrogen receptor modulator, is currently FDA-approved for treating infertility in women whose ovaries fail to produce adequate numbers of eggs.19 But doctors have begun prescribing it off-label for use in men with low testosterone after a series of clinical studies showed it to be both safe and effective as a testosterone booster

It protects hair follicles from oxidative stress and environmental damage

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Modulation of lymphocyte functions and immune responses by cysteine and cysteine derivatives