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However, NLY01, a brain-penetrant, pegylated, longer-lasting version of exenatide, provided no significant benefits in PD patients with a H&Y stage of 2.5 and an average disease duration of 1 year, as assessed by the MDS-UPDRS Parts II and III scores

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Although several observational real-world studies of semaglutide OW have been undertaken [21,22,23,24,25,26,27,28,29,30,31], evidence concerning its relative effectiveness versus other interventions (including SGLT2is) in the real-world setting is limited

We found that PA-S14 promotes mitochondrial biogenesis via LKB1-AMPK-PGC-1 signaling pathway, which protects against renal TECs cell senescence, renal fibrosis in various CKD models, such as unilateral ureteral obstruction (UUO), unilateral ischemia-reperfusion injury (UIRI), adriamycin nephropathy and 5/6 nephrectomized model (Table 1)