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By increasing tight junction proteins, decreasing intestinal permeability, and lowering endotoxemia a known cause of vascular inflammation and atherogenesis probiotics also improve the integrity of the gut barrier

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The majority of the reported events occurred in patients who experienced gastrointestinal reactions leading to dehydration such as nausea, vomiting, or diarrhea [see Adverse Reactions (6)]

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Not because these medications are inherently harmful, but because any powerful metabolic intervention deserves thoughtful oversight