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Oral administration results in rapid degradation by gastric acid and hepatic first-pass metabolism, rendering the compounds inactive before reaching systemic circulation
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From a safety perspective, gastrointestinal adverse effects are the most commonly reported for GLP-1 RAs, with nausea, vomiting, and diarrhea remaining the leading causes of treatment discontinuation [7]
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It notes that losing body weight itself reduces systemic inflammation, so improvement after treatment is confounded
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