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Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network

Chloroquine (CQ) and L-Arginine (100 mg/kg) treated tissues exhibited severe damage with disruption, vacuolization, thickness of epidermis (first skin layer) and deformed cells

Protocol approach 1: immune rebalancing (thymosin alpha-1 plus KPV) Goal: Restore regulatory immune function while reducing inflammatory signaling Components: Thymosin alpha-1: 1.6 mg subcutaneously twice per week (promotes Treg expansion, modulates dendritic cells) KPV: 200-500 mcg daily, orally or subcutaneously (inhibits NF-kB, reduces TNF-alpha and IL-6) Rationale: Thymosin alpha-1 works at the cellular level to rebuild the regulatory arm of the immune system, while KPV addresses the inflammatory signaling that drives acute symptoms

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Curr Top Med Chem 13(21):26482659 Barneche S, Albors S, Borthagaray G, Cerdeiras MP, Vzquez A (2017) Anti-MRSA activ ity of fruiting body extracts of spectacular Rustgill mushroom, Gymnopilus junonius (Agaricomycetes)