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The protein family is evolutionarily conserved in nearly all eukaryotes, only missing in a few, highly diverged eukaryotes such as Giardia lamblia and Encephalitozoon cuniculi 4

Host-directed therapy (HDT) has gained recognition as a promising approach in TB treatment

37 Moreover, the survival of drug-resistant cancer cells is dependent on GPX4, which plays a key role in cell death (ferroptosis) and is considered a novel target of anticancer drugs

Introduction Glutathione transferases are the most important family of enzymes involved in the metabolism of alkylating compounds and their metabolites

Ahmed S, Lindsey B, Davies J