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Nat Rev Neurosci 9, 568578 (2008)

& Panayi, G

Randomized controlled trials have confirmed the homocysteine-raising effect of coffee intakes of about four cups/day

The result is disappointment and possibly inflammation from all that cellular activity going nowhere

Impaired homocysteine metabolism-mediated moderate hyperhomocysteinemia (caused by folate deficiency, vitamin B 6 deficiency, or by methionine excess) might thus have primarily pro-oxidant effects resulting from an altered extra- and intracellular redox potential that can affect essential vascular functions