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Patients considering these medications should discuss their history of gastrointestinal issues with their healthcare provider to set realistic expectations and develop strategies for managing potential side effects during the critical early treatment period

Recently, in these terms (activation of the collateral pathways, relayed on the given injury) [11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28], we reviewed the greater pleiotropic cytoprotection potential of the stable gastric pentadecapeptide BPC 157 as a novel cytoprotection mediator largely involved in healing (for review, see i.e., [1,2,3,4,5,6]), inside and outside the gastrointestinal tract (i.e., BPC 157 counteracted leaky gut (for review, see i.e., [4])