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5,6 Additionally, high glucose levels negatively impact osteoblast function, contributing to bone defects partly through the production of advanced glycation end-products (AGEs), which upregulates sclerostin, an inhibitor of osteoblast activity

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This feature helps prevent abnormal activation of glycolysis under non-pathological conditions and preserves the dominant role of fatty acid oxidation in cardiac energy metabolism (62)

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Beginner Full-Body Routine (2x/Week) If you're new to strength training, start with this simple routine twice weekly (Monday and Thursday, for example): Workout A: Goblet Squats: 3 sets 8-12 reps Push-ups (modified on knees if needed): 3 sets 8-15 reps Bent-Over Dumbbell Rows: 3 sets 10-12 reps Planks: 3 sets 20-45 seconds Workout B (next session): Lunges: 3 sets 10 reps per leg Chest Press with dumbbells: 3 sets 8-12 reps Lat Pulldowns or Assisted Pull-ups: 3 sets 8-12 reps Dead Bugs: 3 sets 12 reps per side Intermediate Upper/Lower Split (4x/Week) Once comfortable, progress to this four-day split: Monday - Lower Body: Squats or Leg Press: 4 sets 8-10 reps Romanian Deadlifts: 3 sets 10-12 reps Leg Curls: 3 sets 12-15 reps Calf Raises: 3 sets 15-20 reps Tuesday - Upper Body: Bench Press or Push-ups: 4 sets 8-10 reps Rows: 4 sets 8-10 reps Overhead Press: 3 sets 10-12 reps Bicep Curls: 3 sets 12-15 reps Thursday - Lower Body: Deadlifts or Leg Press: 4 sets 8-10 reps Lunges: 3 sets 10-12 reps per leg Leg Extensions: 3 sets 12-15 reps Planks: 3 sets 30-60 seconds Friday - Upper Body: Incline Press: 4 sets 8-10 reps Pull-ups or Pulldowns: 4 sets 8-10 reps Lateral Raises: 3 sets 12-15 reps Tricep Dips or Extensions: 3 sets 12-15 reps Progressive Overload: The Key to Muscle Preservation Each week, try to either: Add 1-2 reps per set, OR Increase weight by 2.5-5 lbs, OR Slow down the movement tempo (3 seconds down, 1 second up) This progression signals your body: "We need this muscle for these increasingly challenging taskspreserve it." What About Cardio