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doi: 10.1017/S0007114517002999 256

However, it's crucial to approach its use with caution, adhering to proper safety guidelines and expert advice

When activated, Nrf2 disassociates from its repressor protein KEAP1 that reacts with oxidative radicals, translocates to the nucleus, binds to antioxidant response element and induces the transcription of defensive genes

Under constant exposure of UV radiation, the cutaneous layer demonstrates a propensity for epigenetic shifts, such as the methylation of genomic DNA, histone acetylation and the posttranscriptional governance of noncoding RNAs, which leads to skin cancer [141,142,143,144,145,146,147,148]

Just note: the data on the benefits and risks of supplementation remains unclear, particularly as it relates to using vitamin D and calcium supplements together