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Partial least squares-discrimination analysis (PLS-DA) and the heatmap showed a clear classification of the metabolomes between four groups ( Figures 2A, B )

Heil and Kottilil, 2022)

It involves the participation of intracellular and extracellular NAD + -synthesizing and -consuming enzymes, as well as specific cell transporters that facilitate the transport and uptake of nicotinamide-related metabolites [70]

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reported that genetic deletion or pharmacological inhibition of DHODH did not substantially alter ferroptosis sensitivity across multiple cellular models, suggesting that its protective role may be overstated or highly context dependent 92