The FDA approved saxagliptin, linagliptin, and alogliptin, and the European Union and Japan approved vildagliptin, anagliptin, teneligliptin, trelagliptin, and omarigliptin
Tailoring treatment to the individual is a complex task that must consider several factors, including the severity of adiposity, the presence and extent of complications, comorbidities and concurrent therapies
22,32 In a large-scale real-world cohort study of more than 10,000 patients using a GLP-1 RA, abdominal pain was the most common symptom (57.6%), followed by constipation (30.4%), diarrhea (32.7%), and nausea/vomiting (23.4%)
The decision notice letter will clearly indicate what is approved or what correction or additional information is needed to continue adjudicating the PA request
Mittman BG, Le P, Payne JY, Ayers G, Rothberg MB