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367 In vitro, Erv1 can be reoxidized by oxygen to generate hydrogen peroxide, but in vivo, it primarily transfers electrons to cytochrome c, connecting to the respiratory chain and improving reoxidation efficiency while inhibiting hydrogen peroxide buildup in the IMS

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Increasing GSH levels through precursor supplementation is a feasible intervention that directly addresses OxS in diabetes

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The initial clinical studies on fisetin, and others, will be critical to inform the field on the safe use of natural compounds as senolytic therapies